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Báo cáo y học: " Low NO bioavailability in CCl4 cirrhotic rat livers might result from low NO synthesis combined with decreased superoxide dismutase activity allowing superoxide-mediated NO breakdown: A comparison of two portal hypertensive rat models with healthy controls"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Low NO bioavailability in CCl4 cirrhotic rat livers might result from low NO synthesis combined with decreased superoxide dismutase activity allowing superoxide-mediated NO breakdown: A comparison of two portal hypertensive rat models with healthy controls. | Comparative Hepatology BioMed Central Research Open Access Low NO bioavailability in CCl4 cirrhotic rat livers might result from low NO synthesis combined with decreased superoxide dismutase activity allowing superoxide-mediated NO breakdown A comparison of two portal hypertensive rat models with healthy controls Marc Van de Casteele 1 Jos F van Pelt1 Frederik Nevens1 Johan Fevery1 and Jurg Reichen2 Address Department of Hepatology Catholic University of Leuven Herestraat 49 B-3000 Leuven B-3000 Leuven Belgium and 2Institute of Clinical Pharmacology University of Berne Murtenstrasse 35 CH-3010 Berne Switzerland Email Marc Van de Casteele - marc.vandecasteele@uz.kuleuven.ac.be Jos F van Pelt - jos.vanpelt@med.kuleuven.ac.be Frederik Nevens - frederik.nevens@uz.kuleuven.ac.be Johan Fevery - johan.fevery@uz.kuleuven.ac.be Jurg Reichen - juerg.reichen@ikp.unibe.ch Corresponding author Published 10 January 2003 Received 29 August 2002 Accepted 10 January 2003 Comparative Hepatology 2003 2 2 This article is available from http www.comparative-hepatology.cOm content 2 l 2 2003 Van de Casteele et al licensee BioMed Central Ltd. This is an Open Access article verbatim copying and redistribution of this article are permitted in all media for any purpose provided this notice is preserved along with the article s original URL. Abstract Background In cirrhotic livers the balance of vasoactive substances is in favour of vasoconstrictors with relatively insufficient nitric oxide. Endothelial dysfunction has been documented in cirrhotic rat livers leading to a lower activity of endothelial nitric oxide synthase but this might not be sufficient to explain the low nitric oxide presence. We compared the amount of all nitric oxide synthase isoforms and other factors that influence nitric oxide bioavailability in livers of two portal hypertensive rat models prehepatic portal hypertension and carbon tetrachloride induced cirrhosis in comparison with healthy controls. Results Endothelial