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Báo cáo y học: "Morphological characterisation of portal myofibroblasts and hepatic stellate cells in the normal dog liver"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Morphological characterisation of portal myofibroblasts and hepatic stellate cells in the normal dog liver. | BioMed Central Comparative Hepatology Research Open Access Morphological characterisation of portal myofibroblasts and hepatic stellate cells in the normal dog liver Jooske IJzer 1 Tania Roskams2 Ronald F Molenbeek1 Ton Ultee1 Louis C Penning3 Jan Rothuizen3 and Ted SGAM van den Ingh4 Address Department of Pathobiology Faculty of Veterinary Medicine Utrecht University The Netherlands 2Laboratory of Morphology and Molecular Pathology University of Leuven K.U. Leuven Leuven Belgium 3Department of Clinical Sciences of Companion Animals Faculty of Veterinary Medicine Utrecht University The Netherlands and 4TCCI Consultancy BV PO Box 85032 3508 AA Utrecht The Netherlands Email Jooske IJzer - j.ijzer@vet.uu.nl Tania Roskams - tania.roskams@uz.kuleuven.ac.be Ronald F Molenbeek - R.Molenbeek@vet.uu.nl Ton Ultee - T.Ultee@vet.uu.nl Louis C Penning - L.C.Penning@vet.uu.nl Jan Rothuizen - J.Rothuizen@vet.uu.nl Ted SGAM van den Ingh - T.S.G.A.M.vandenIngh@wanadoo.nl Corresponding author Published 16 November 2006 Received 04 July 2005 Accepted 16 November 2006 Comparative Hepatology 2006 5 7 doi 10.1186 1476-5926-5-7 r This article is available from http www.comparative-hepatology.com content 5 1 7 2006 IJzer et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Hepatic fibrosis is a common outcome of hepatic injury in both man and dog. Activated fibroblasts which develop myofibroblastic characteristics play an essential role in hepatic fibrogenesis and are comprised of three subpopulations 1 portal or septal myofibroblasts 2 interface myofibroblasts and 3 the perisinusoidally located hepatic stellate cells HSC . The present study was performed to investigate the immunohistochemical characteristics of canine portal