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Báo cáo y học: "Bile constituents in hibernating golden-mantled ground squirrels (Spermophilus lateralis)"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Bile constituents in hibernating golden-mantled ground squirrels (Spermophilus lateralis). | Comparative Hepatology BioMed Central Research Bile constituents in hibernating golden-mantled ground squirrels Spermophilus lateralis Julie A Baker and Frank van Breukelen Address School of Life Sciences University of Nevada Las Vegas 4505 Maryland Parkway Las Vegas Nevada 89154 USA Email Julie A Baker - abaker1170@aol.com Frank van Breukelen - frank.vanbreukelen@unlv.edu Corresponding author Open Access Published 26 May 2009 Received 15 October 2008 Comparative Hepatology 2009 8 2 doi 10.1186 1476-5926-8-2 Accepted 26 May 2009 This article is available from http www.comparative-hepatology.cOm content 8 1 2 2009 Baker and van Breukelen licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Golden-mantled ground squirrels S. lateralis are anorexic during the winter and survive by exploiting hibernation to reduce energetic demands. The liver normally plays a critical role in fueling and regulating metabolism and one might expect significant changes in hepatobiliary function with hibernation. We analyzed bile collected from animals in summer animals in winter that were either torpid active between bouts of torpor or which failed to enter hibernation in order to characterize the effects of hibernation on hepatobiliary function per se. Results Surprisingly hibernator bile did not differ from summer squirrel bile in key characteristics including bile acids cholesterol free fatty acids lecithin and osmolality. One major distinction between summer and winter squirrels was that winter squirrels experience 5 fold increases in bilirubin . Such an increase may have significant physiological consequences that could aid in survivorship of torpor. Animals that failed to hibernate despite being anorexic were very similar to .