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Báo cáo y học: "Daytime food restriction alters liver glycogen, triacylglycerols, and cell size. A histochemical, morphometric, and ultrastructural study"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Daytime food restriction alters liver glycogen, triacylglycerols, and cell size. A histochemical, morphometric, and ultrastructural study. | Diaz-Munoz et al. Comparative Hepatology 2010 9 5 http www.comparative-hepatology.eom content 9 1 5 COMPARATIVE HEPATOLOGY RESEARCH Open Access Daytime food restriction alters liver glycogen triacylglycerols and cell size. A histochemical morphometric and ultrastructural study Mauricio Diaz-Munoz1 Olivia Vazquez-Martinez1 Adrian Baez-Ruiz1 Gema Martinez-Cabrera1 María V Soto-Abraham2 María C Ávila-Casado2 Jorge Larriva-Sahd Abstract Background Temporal restriction of food availability entrains circadian behavioral and physiological rhythms in mammals by resetting peripheral oscillators. This entrainment underlies the activity of a timing system different from the suprachiasmatic nuclei SCN known as the food entrainable oscillator FEO . So far the precise anatomical location of the FEO is unknown. The expression of this oscillator is associated with an enhanced arousal prior to the food presentation that is called food anticipatory activity FAA . We have focused on the study of the role played by the liver as a probable component of the FEO. The aim of this work was to identify metabolic and structural adaptations in the liver during the expression of the FEO as revealed by histochemical assessment of hepatic glycogen and triacylglycerol contents morphometry and ultrastructure in rats under restricted feeding schedules RFS . Results RFS promoted a decrease in the liver body weight ratio prior to food access a reduction of hepatic water content an increase in cross-sectional area of the hepatocytes a moderate reduction in glycogen content and a striking decrease in triacylglyceride levels. Although these adaptation effects were also observed when the animal displayed FAA they were reversed upon feeding. Mitochondria observed by electron microscopy showed a notorious opacity in the hepatocytes from rats during FAA 11 00 h . Twenty four hour fasting rats did not show any of the modifications observed in the animals expressing the FEO. Conclusions Our results .