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Báo cáo y học: "Hydroxyethylstarch impairs renal function and induces interstitial proliferation, macrophage infiltration and tubular damage in an isolated renal perfusion model"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Hydroxyethylstarch impairs renal function and induces interstitial proliferation, macrophage infiltration and tubular damage in an isolated renal perfusion model. | Available online http ccforum.eom content 13 1 R23 Research Hydroxyethylstarch impairs renal function and induces interstitial proliferation macrophage infiltration and tubular damage in an isolated renal perfusion model Lars Huter1 Tim-Philipp Simon2 Lenard Weinmann1 Tobias Schuerholz2 Konrad Reinhart1 Gunter Wolf3 Kerstin Ute Amann4 and Gernot Marx2 Open Access Department of Anaesthesiology and Intensive Care Medicine University of Jena Erlanger Allee Jena 07747 Germany 2Department of Surgical Intensive Care University of Aachen Pauwelsstrasse Aachen 52074 Germany 3Department of Internal Medicine III University of Jena Erlanger Allee Jena 07747 Germany 4Department of Pathology University of Erlangen Universitatsstr. Erlangen 91054 Germany Corresponding author Gernot Marx gmarx@ukaachen.de Received 7 Aug 2008 Revisions requested 21 Aug 2008 Revisions received 4 Oct 2008 Accepted 25 Feb 2009 Published 25 Feb 2009 Critical Care 2009 13 R23 doi 10.1186 cc7726 This article is online at http ccforum.com content 13 1 R23 2009 Huter et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Introduction The aim of the study was to evaluate some of the underlying pathomechanisms of hydroxyethylstarch HES induced adverse effects on renal function using 24 porcine kidneys in an isolated perfusion model over six hours. Methods Infusion of either 10 HES 200 0.5 6 HES 130 0.42 or Ringer s lactate RL was performed to achieve an haematocrit of 20 in eight kidneys from four animals per group. Physiological and pathophysiological parameters were determined including N-acetyl-beta-aminoglucosidase as a marker for lysosomal tubular damage . Histological investigations and immunohistological stainings of the kidneys were performed. .