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Báo cáo y học: "Research Chemotherapy in conjoint aging-tumor systems: some simple models for addressing coupled aging-cancer dynamics"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: Research Chemotherapy in conjoint aging-tumor systems: some simple models for addressing coupled aging-cancer dynamics. | Feizabadi and Witten Theoretical Biology and Medical Modelling 2010 7 21 http www.tbiomed.eom content 7 1 21 THEORETICAL BIOLOGY AND MEDICAL MODELLING RESEARCH Open Access Chemotherapy in conjoint aging-tumor systems some simple models for addressing coupled aging-cancer dynamics Mitra S Feizabadi 1 and Tarynn M Witten 2 Correspondence shojanmi@shu.edu tmwitten@vcu.edu 1 Physics Department Seton Hall University South Orange NJ07079 UsA 2 Center for the Study of Biological Complexity Virginia Commonwealth University Abstract Background In this paper we consider two approaches to examining the complex dynamics of conjoint aging-cancer cellular systems undergoing chemotherapeutic intervention. In particular we focus on the effect of cells growing conjointly in a culture plate as a precursor to considering the larger multi-dimensional models of such systems. Tumor cell growth is considered from both the logistic and the Gompertzian case while normal cell growth of fibroblasts WI-38 human diploid fibroblasts is considered as logistic only. Results We demonstrate in a simple approach how the interdependency of different cell types in a tumor together with specifications of for treatment can lead to different evolutionary patterns for normal and tumor cells during a course of therapy. Conclusions These results have significance for understanding appropriate pharmacotherapy for elderly patients who are also undergoing chemotherapy. Prologia In 1976 I TMW attended a small meeting at the W. Alton Jones Cell Science Center a research center in upstate New York. I was a young graduate student and one of the presenters was a then very young James Smith. He presented a talk on WI-38 human diploid fibroblast doubling and aging 1 . The results of his work lead to clonal fibroblast data distributions that looked surprisingly similar to my Master s degree modeling work on recombination of tandem gene repeats and their possible relationship to aging and cancer 2 3 . I was immediately