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Báo cáo y học: "Thromboelastometry for the assessment of coagulation abnormalities in early and established adult sepsis: a prospective cohort study"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Thromboelastometry for the assessment of coagulation abnormalities in early and established adult sepsis: a prospective cohort study. | Available online http ccforum.eom content 13 2 R42 Research Thromboelastometry for the assessment of coagulation abnormalities in early and established adult sepsis a prospective cohort study Fritz Daudel1 Ulf Kessler2 Hélène Folly1 Jasmin S Lienert1 Jukka Takala1 and Stephan M Jakob1 Department of Intensive Care Medicine Inselspital Bern University Hospital and University of Bern Freiburgstrasse 301 0 Bern Switzerland department of Pediatric Surgery Inselspital Bern University Hospital and University of Bern Freiburgstrasse 301 0 Bern Switzerland Corresponding author Fritz Daudel fritz.daudel@insel.ch Received 18 Nov 2008 Revisions requested 10 Dec 2008 Revisions received 6 Mar 2009 Accepted 30 Mar 2009 Published 30 Mar 2009 Critical Care 2009 13 R42 doi 10.1186 cc7765 This article is online at http ccforum.com content 13 2 R42 2009 Daudel et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Introduction The inflammatory response to an invading pathogen in sepsis leads to complex alterations in hemostasis by dysregulation of procoagulant and anticoagulant factors. Recent treatment options to correct these abnormalities in patients with sepsis and organ dysfunction have yielded conflicting results. Using thromboelastometry ROTEM we assessed the course of hemostatic alterations in patients with sepsis and related these alterations to the severity of organ dysfunction. Methods This prospective cohort study included 30 consecutive critically ill patients with sepsis admitted to a 30-bed multidisciplinary intensive care unit ICU . Hemostasis was analyzed with routine clotting tests as well as thromboelastometry every 12 hours for the first 48 hours and at discharge from the ICU. Organ dysfunction was .