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Báo cáo y học: " Interactomes, manufacturomes and relational biology: analogies between systems biology and manufacturing systems"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: " Interactomes, manufacturomes and relational biology: analogies between systems biology and manufacturing systems | Rietman et al. Theoretical Biology and Medical Modelling 2011 8 19 http www.tbiomed.eom content 8 1 19 THEORETICAL BIOLOGY AND MEDICAL MODELLING RESEARCH Open Access Interactomes manufacturomes and relational biology analogies between systems biology and manufacturing systems Edward A Rietman1 2 6 John Z Colt3 and Jack A Tuszynski4 5 Correspondence jackt@ualberta. ca department of Experimental Oncology Cross Cancer Institute 11560 University Av. Edmonton AB T6G 1Z2 Canada Full list of author information is available at the end of the article 2 BioMed Central Abstract Background We review and extend the work of Rosen and Casti who discuss category theory with regards to systems biology and manufacturing systems respectively. Results We describe anticipatory systems or long-range feed-forward chemical reaction chains and compare them to open-loop manufacturing processes. We then close the loop by discussing metabolism-repair systems and describe the rationality of the self-referential equation f f f . This relationship is derived from some boundary conditions that in molecular systems biology can be stated as the cardinality of the following molecular sets must be about equal metabolome genome proteome. We show that this conjecture is not likely correct so the problem of self-referential mappings for describing the boundary between living and nonliving systems remains an open question. We calculate a lower and upper bound for the number of edges in the molecular interaction network the interactome for two cellular organisms and for two manufacturomes for CMOS integrated circuit manufacturing. Conclusions We show that the relevant mapping relations may not be Abelian and that these problems cannot yet be resolved because the interactomes and manufacturomes are incomplete. Background Systems biology is a domain that generally encompasses both large-scale organismal systems 1 and smaller-scale cellular systems 2 . The majority of contemporary systems biology falls under