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Báo cáo y học: " Bench-to-bedside review: Carbon monoxide - from mitochondrial poisoning to therapeutic use"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Bench-to-bedside review: Carbon monoxide - from mitochondrial poisoning to therapeutic use. | Available online http ccforum.eom content 13 4 220 Review Bench-to-bedside review Carbon monoxide - from mitochondrial poisoning to therapeutic use Inge Bauer and Benedikt HJ Pannen University Hospital Duesseldorf Department of Anesthesiology Moorenstrasse 5 D-40225 Duesseldorf Germany Corresponding author Inge Bauer Inge.Bauer@uni-duesseldorf.de Published 14 August 2009 This article is online at http ecforum.eom eontent 13 4 220 2009 BioMed Central Ltd Critical Care 2009 13 220 doi 10.1186 cc7887 Abstract Carbon monoxide CO is generated during incomplete combustion of carbon-containing compounds and leads to acute and chronic toxicity in animals and humans depending on the concentration and exposure time. In addition to exogenous sources CO is also produced endogenously by the activity of heme oxygenases HOs and the physiological significance of HO-derived CO has only recently emerged. CO exerts vasoactive anti-proliferative antioxidant anti-inflammatory and anti-apoptotic effects and contributes substantially to the important role of the inducible isoform HO-1 as a mediator of tissue protection and host defense. Exogenous application of low doses of gaseous CO might provide a powerful tool to protect organs and tissues under various stress conditions. Experimental evidence strongly suggests a beneficial effect under pathophysiological conditions such as organ transplantation ischemia reperfusion inflammation sepsis or shock states. The cellular and molecular mechanisms mediating CO effects are only partially characterized. So far only a few studies in humans are available which however do not support the promising results observed in experimental studies. The protective effects of exogenous CO may strongly depend on the pathological condition the mode time point and duration of application the administered concentration and on the target tissue and cell. Differences in bioavailability of endogenous CO production and exogenous CO supplementation might also provide