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Báo cáo y học: "Early drotrecogin alpha (activated) administration in severe sepsis is associated with lower mortality: a retrospective analysis of the Canadian ENHANCE cohort"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Early drotrecogin alpha (activated) administration in severe sepsis is associated with lower mortality: a retrospective analysis of the Canadian ENHANCE cohort. | Available online http ccforum.eom content 13 3 R78 Research Early drotrecogin alpha activated administration in severe sepsis is associated with lower mortality a retrospective analysis of the Canadian ENHANCE cohort Richard V Hodder1 Richard Hall2 James A Russell3 Harold N Fisher4 and Bobbie Lee5 Open Access Divisions of Pulmonary and Critical Care Medicine University of Ottawa The Ottawa Hospital 1053 Carling Ave Ottawa ON Canada K1Y4E9 Departments of Anesthesiology Medicine and Pharmacology Associate Professor of Surgery Dalhousie University The Queen Elizabeth II Health Sciences Centre 1796 Summer St Halifax NS Canada B3H 3A7 3iCAPTURE Centre for Cardiovascular and Pulmonary Research St. Paul s Hospital 1081 Burrard St. Vancouver BC Canada V6Z 1Y6 4Eli Lilly Canada Inc. 3650 Danforth Ave Toronto ON Canada M1 N 2E8 5Eli Lilly Canada Inc. Eli Lilly Canada Inc. 3650 Danforth Ave Toronto ON Canada M1N 2E8 Corresponding author Richard V Hodder rhodder@ottawahospital.on.ca Received 7 Nov 2008 Revisions requested 3 Dec 2008 Revisions received 4 Apr 2009 Accepted 20 May 2009 Published 20 May 2009 Critical Care 2009 13 R78 doi 10.1186 cc7893 This article is online at http ccforum.com content 13 3 R78 2009 Hodder et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Introduction Early multimodal treatment of severe sepsis including the use of drotrecogin alfa activated DrotAA when indicated is considered essential for optimum outcome. However predicting which infected patients will progress to severe sepsis and the need for aggressive intervention continues to be problematic. We therefore wished to explore whether there were any potential early markers that might predict improved survival in response to early use of .