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Báo cáo y học: "Child/Adolescent Anxiety Multimodal Study (CAMS): rationale, design, and methods"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Child/Adolescent Anxiety Multimodal Study (CAMS): rationale, design, and methods. | Compton et al. Child and Adolescent Psychiatry and Mental Health 2010 4 1 http www.capmh.eom content 4 1 1 CHILD ADOLESCENT PSYCHIATRY MENTAL HEALTH REVIEW Open Access Child Adolescent Anxiety Multimodal Study CAMS rationale design and methods 0 z z l I m k . r 1 4 I fs A k k I A 11 1 I k .2 4 A k S k S Z ỉ l n Al k k 3 Di i nti ni44 o lA r- D I K m V5 4 I fs Z I I 0 A rr i I 164 Scott N Compton John I vVdiKup Anne Marie Albano John C Piacentini Boris Birmaher Joel I Sherrill f _ r I Z l c 11 k k I I I ZZI 2 4 h I fs I K A D k S k k34 I r I A I r- - Z-Izz x k k44 o KI r f rA r I I Z lz74 r A l r k k z t K5 4 D A I I I I k A J x k kZ l ll84 Golda S Ginsburg Moira A Rynn James I MccracKen Bruce D vvasliCK Satish Iyengar Phillip C Kendall John s March14 Abstract Objective To present the design methods and rationale of the Child Adolescent Anxiety Multimodal Study CAMS a recently completed federally-funded multi-site randomized placebo-controlled trial that examined the relative efficacy of cognitive-behavior therapy CBT sertraline SRT and their combination COMB against pill placebo PBO for the treatment of separation anxiety disorder SAD generalized anxiety disorder GAD and social phobia SoP in children and adolescents. Methods Following a brief review of the acute outcomes of the CAMS trial as well as the psychosocial and pharmacologic treatment literature for pediatric anxiety disorders the design and methods of the CAMS trial are described. Results CAMS was a six-year six-site randomized controlled trial. Four hundred eighty-eight N 488 children and adolescents ages 7-17 years with DSM-IV-TR diagnoses of SAD GAD or SoP were randomly assigned to one of four treatment conditions CBT SRT COMB or PBO. Assessments of anxiety symptoms safety and functional outcomes as well as putative mediators and moderators of treatment response were completed in a multimeasure multi-informant fashion. Manual-based therapies trained clinicians and independent evaluators were used to .