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Báo cáo y học: "Early release of high mobility group box nuclear protein 1 after severe trauma in humans: role of injury severity and tissue hypoperfusion"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Early release of high mobility group box nuclear protein 1 after severe trauma in humans: role of injury severity and tissue hypoperfusion. | Available online http ccforum.eom content 13 6 R174 Research Early release of high mobility group box nuclear protein 1 after severe trauma in humans role of injury severity and tissue hypoperfusion Mitchell J Cohen1 Karim Brohi2 Carolyn S Calfee3 Pamela Rahn1 Brian B Chesebro4 Sarah C Christiaans1 Michel Carles4 Marybeth Howard4 and Jean-Franọois Pittet4 1The Department of Surgery San Francisco General Hospital University of California San Francisco 1001 Potrero Avenue San Francisco CA 94110 UsA 2The Royal London Hospital Whitechapel London E1 1BB UK 3The Department of Medicine San Francisco General Hospital University of California San Francisco 1001 Potrero Avenue San Francisco CA 94114 USA 4The Department of Anesthesia San Francisco General Hospital University of California San Francisco 1 001 Potrero Avenue San Francisco CA 94110 USA Corresponding author Mitchell J Cohen mcohen@sfghsurg.ucsf.edu Received 22 Jan 2009 Revisions requested 10 Mar 2009 Revisions received 5 Jun 2009 Accepted 4 Nov 2009 Published 4 Nov 2009 Critical Care 2009 13 R174 doi 10.1186 cc8152 This article is online at http ccforum.com content 13 6 R1 74 2009 Cohen et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Introduction High mobility group box nuclear protein 1 HMGB1 is a DNA nuclear binding protein that has recently been shown to be an early trigger of sterile inflammation in animal models of trauma-hemorrhage via the activation of the Toll-like-receptor 4 TLR4 and the receptor for the advanced glycation endproducts RAGE . However whether HMGB1 is released early after trauma hemorrhage in humans and is associated with the development of an inflammatory response and coagulopathy is not known and therefore constitutes