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Báo cáo y học: "HES 130/0.4 impairs haemostasis and stimulates pro-inflammatory blood platelet function"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: HES 130/0.4 impairs haemostasis and stimulates pro-inflammatory blood platelet function. | Available online http ccforum.eom content 13 6 R208 Research HES 130 0.4 impairs haemostasis and stimulates pro-inflammatory blood platelet function Maik Sossdorf Sascha Marx Barbara Schaarschmidt Gordon P Otto Ralf A Claus Konrad Reinhart Christiane S Hartog and Wolfgang Losche Department of Anaesthesiology and Intensive Care Therapy Jena University Hospital Erlanger Allee 101 D-07740 Jena Germany Corresponding author Maik Sossdorf maik.sossdorf@med.uni-jena.de Received 4 Sep 2009 Revisions requested 5 Nov 2009 Revisions received 17 Nov 2009 Accepted 22 Dec 2009 Published 22 Dec 2009 Critical Care 2009 13 R208 doi 10.1186 cc8223 This article is online at http ccforum.com content 13 6 R208 2009 Sossdorf et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Introduction Hydroxyethyl starch HES solutions are widely used for volume replacement therapy but are also known to compromise coagulation impair renal function and increase long-term mortality. To test the hypotheses that HES 130 0.4 has fewer adverse effects than HES 200 0.5 and exerts antiinflammatory properties we compared the effects of HES 130 0.4 HES 200 0.5 and saline on in vitro haemostasis and pro-inflammatory platelet function. Methods Whole blood samples from healthy volunteers were mixed with 6 HES 130 0.4 10 HES 200 0.5 or normal saline to achieve a final haemodilution rate of 10 or 40 . Haemostatic capacity was characterised by thromboelastography ROTEM and measurement for FXIIIa activity. Platelet activation and pro-inflammatory platelet functions were characterised by flow cytometry measuring the platelet activation marker CD62P and binding of fibrinogen to platelets as well as the formation of heterotypic plateletleukocyte .