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Báo cáo y học: "Diffusion-weighted magnetic resonance imaging for predicting the clinical outcome of comatose survivors after cardiac arrest: a cohort study"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: Diffusion-weighted magnetic resonance imaging for predicting the clinical outcome of comatose survivors after cardiac arrest: a cohort study. | Choi et al. Critical Care 2010 14 R17 http ccforum.eom content 14 1 R17 c CRITICAL CARE RESEARCH Open Access Diffusion-weighted magnetic resonance imaging for predicting the clinical outcome of comatose survivors after cardiac arrest a cohort study Seung Pill Choi1 Kyu Nam Park1 Hae Kwan Park2 Jee Young Kim3 Chun Song Youn1 Kook Jin Ahn3 Hyeon Woo Yim4 Abstract Introduction The aim of this study was to examine whether the patterns of diffusion-weighted imaging DWI abnormalities and quantitative regional apparent diffusion coefficient ADC values can predict the clinical outcome of comatose patients following cardiac arrest. Methods Thirty-nine patients resuscitated from out-of-hospital cardiac arrest were prospectively investigated. Within five days of resuscitation axial DWIs were obtained and ADC maps were generated using two 1.5-T magnetic resonance scanners. The neurological outcomes of the patients were assessed using the Glasgow Outcome Scale GOS score at three months after the cardiac arrest. The brain injuries were categorised into four patterns normal isolated cortical injury isolated deep grey nuclei injury and mixed injuries cortex and deep grey nuclei . Twenty-three subjects with normal DWIs served as controls. The ADC and percent ADC values the ADC percentage as compared to the control data from the corresponding region were obtained in various regions of the brains. We analysed the differences between the favourable GOS score 4 to 5 and unfavourable GOS score 1 to 3 groups with regard to clinical data the DWI abnormalities and the ADC and percent ADC values. Results The restricted diffusion abnormalities in the cerebral cortex caudate nucleus putamen and thalamus were significantly different between the favourable n 13 and unfavourable n 26 outcome groups. The cortical pattern of injury was seen in one patient 3 the deep grey nuclei pattern in three patients 8 the cortex and deep grey nuclei pattern in 21 patients 54 and normal DWI findings in 14 .