Đang chuẩn bị liên kết để tải về tài liệu:
Báo cáo y học: "Preadmission statin use and one-year mortality among patients in intensive care - A cohort study"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: Preadmission statin use and one-year mortality among patients in intensive care - A cohort study. | Christensen et al. Critical Care 2010 14 R29 http ccforum.eom content 14 2 R29 c CRITICAL CARE RESEARCH Open Access Preadmission statin use and one-year mortality among patients in intensive care - A cohort study Steffen Christensen1 Reimar W Thomsen1 Martin B Johansen1 Lars Pedersen1 Reinhold Jensen2 Kim M Larsen3 Anders Larsson4 Else T0nnesen3 Henrik Toft S0rensen1 Abstract Introduction Statins reduce risk of cardiovascular events and have beneficial pleiotropic effects both may reduce mortality in critically ill patients. We examined whether statin use was associated with risk of death in general intensive care unit ICU patients. Methods Cohort study of 12 483 critically ill patients 45 yrs of age with a first-time admission to one of three highly specialized ICUs within the Aarhus University Hospital network Denmark between 2001 and 2007. Statin users were identified through population-based prescription databases. We computed cumulative mortality rates 0-30 days and 31-365 days after ICU admission and mortality rate ratios MRRs using Cox regression analysis controlling for potential confounding factors demographics use of other cardiovascular drugs comorbidity markers of social status diagnosis and surgery . Results 1882 14.3 ICU patients were current statin users. Statin users had a reduced risk of death within 30 days of ICU admission users 22.1 vs. non-users 25.0 adjusted MRR 0.76 95 confidence interval CI 0.69 to 0.86 . Statin users also had a reduced risk of death within one year after admission to the ICU users 36.4 vs. non-users 39.9 adjusted MRR 0.79 95 CI 0.73 to 0.86 . Reduced risk of death associated with current statin use remained robust in various subanalyses and in an analysis using propensity score matching. Former use of statins and current use of non-statin lipid-lowering drugs were not associated with reduced risk of death. Conclusions Preadmission statin use was associated with reduced risk of death following intensive care. The .