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Báo cáo y học: "Right man, right time, right place"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: Right man, right time, right place? . | Hauser and Radermacher Critical Care 2010 14 190 http ccforum.eom content 14 4 190 CRITICAL CARE COMMENTARY L__ Right man right time right place - On the time course of the mediator orchestra in septic shock Balazs Hauser 1 and Peter Radermacher2 See related research by Lange etal. http ccforum.Com content 14 4 R129 Abstract Appropriate timing of treatment assumes particular importance in critical care. Lange and colleagues recently reported on the time course of the different nitric oxide synthase NOS isoforms nitrosative stress and poly ADP-ribosylation during Pseudomonas aeruginosa pneumonia-induced ovine septic shock. Initially endothelial NOS expression was increased together with markers of peroxynitrite formation DNA damage and nuclear factor-kappa-B activation. Later on measurable NOS activity and nitric oxide production resulted mainly from inducible NOS activation. These results emphasize the need for longterm large-animal studies investigated over days so that future therapeutic interventions can be better tailored and matched to the exact time course of the activation of the mediator orchestra. Timing is everything Appropriate timing of treatment is the key to successful intensive care treatment that is delayed could be as detrimental as treatment that is premature. Therefore Lange and colleagues 1 in this issue of Critical Care reported on the time course of the expression of the different isoforms of the nitric oxide synthase NOS - that is neuronal NOS nNOS inducible NOS iNOS and endothelial NOS eNOS also known as NOS1 NOS2 and NOS3 respectively -of the tissue levels of nitrotyrosine and poly ADP-ribose markers of nitrosative stress and DNA damage resulting from peroxynitrite formation as well as p65 a mirror of the activation of the nuclear factor-kappa-B NF-kB in a well-established resuscitated ovine model of septic shock induced by Pseudomonas aeruginosa pneumonia. Correspondence bhauser1@gmail.com 1Aneszteziológiai és Intenzív Terápiás .