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Báo cáo y học: "Host adaptive immunity deficiency in severe pandemic influenza"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: Host adaptive immunity deficiency in severe pandemic influenza. | Bermejo-Martin et al. Critical Care 2010 14 R167 http ccforum.eom content 14 5 R167 c CRITICAL CARE RESEARCH Open Access Host adaptive immunity deficiency in severe pandemic influenza I Z r I I r c D ft rzzi ft I f. l I I 1 2I Z t f I z R ỉ V f I I ft f n ft r 3 I z zzd I D Z I I z 4 A z l rft r ỉ 5 D Z t I I z I Al m r 1 2 I I I f. Il Z t VI I6 Jesus F Beimejo-Maiun Ignacio Marnn-Loecnes Joidi Reiio Andies Anton Raquel Aimansa LUOling ău Al lillormr t I rt ir iO 7-A nmn ìc7 Trimác D im rrnH5 I if i ici u fi6 P 5i 1I2 p miro- 8 Rutinor6 AcirciL AH01 ilz l ln6 Guiiieimo Lopez campos lomds rUiiiaioia Longsi nan rauia Ramiiez David Bannei Deiek cneuk Ng 9 10 11 12 12 8 Lorenzo Socias Ana Loza David Andaiuz Eniique Maiavi Maiia J Gomez-Sdnchez Monica Goidon 12 12 12 10 14 14 Maiia c Gaiiegos Victoiia Fernandez Saia Aidunate Ciistobai León Pedro Meiino Jesus Bianco 7 1.2 1.2 1.2 5 Fernando Martin-Sanchez Lucia Rico David Vaiiiias Veronica Igiesias Maiia Angeies Maicos Francisco Gandía11 Feiipe Bobiiio11 Begona Nogueira2 Siivia Rojo2 Saivadoi Resino15 Caimen Castio16 Raui Ortiz de Lejaiazu1 2 David Keivin6 17 18 Abstract Introduction Pandemic A H1N1 2009 influenza causes seveie iowei iespiiatoiy compilations in iaie cases. The association between host immune responses and ciinicai outcome in severe cases is unknown. Methods We utiiized gene expression cytokine piofiies and generation of antibody responses foiiowing hospitaiization in 19 ciiticaiiy iii patients with piimaiy pandemic A H1N1 2009 infiuenza pneumonia foi identifying host immune responses associated with ciinicai outcome. Ingenuity pathway anaiysis 8.5 IPA Ingenuity Systems Redwood City CA was used to seiect annotate and visuaiize genes by function and pathway gene ontoiogy . IPA anaiysis identified those canonicai pathways diffeientiaiiy expressed P 0.05 between comparison gioups. Hieiaichicai ciusteiing of those genes diffeientiaiiy expressed between gioups by IPA anaiysis was peifoimed using BRB-Aiiay .