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Báo cáo y học: "Construction of predictive promoter models on the example of antibacterial response of human epithelial cells"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: Construction of predictive promoter models on the example of antibacterial response of human epithelial cells | Theoretical Biology and Medical Modelling BioMed Central Research Open Access Construction of predictive promoter models on the example of antibacterial response of human epithelial cells Ekaterina Shelest 1 and Edgar Wingender1 2 Address 1Dept. of Bioinformatics UKG University of Gottingen Goldschmidtstr. 1 D-37077 Gottingen Germany and 2BIOBASE GmbH Halchtersche Str. 33 D-38304 Wolfenbuttel Germany Email Ekaterina Shelest - katya.shelest@med.uni-goettingen.de Edgar Wingender - e.wingender@med.uni-goettingen.de Corresponding author Published 12 January 2005 Received 16 September 2004 Theoretical Biology and Medical Modelling 2005 2 2 doi 10.1186 1742-4682-2-2 Accepted 12 January 2005 This article is available from http www.tbiomed.cOm content 2 1 2 2005 Shelest and Wingender licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Binding of a bacteria to a eukaryotic cell triggers a complex network of interactions in and between both cells. P. aeruginosa is a pathogen that causes acute and chronic lung infections by interacting with the pulmonary epithelial cells. We use this example for examining the ways of triggering the response of the eukaryotic cell s leading us to a better understanding of the details of the inflammatory process in general. Results Considering a set of genes co-expressed during the antibacterial response of human lung epithelial cells we constructed a promoter model for the search of additional target genes potentially involved in the same cell response. The model construction is based on the consideration of pair-wise combinations of transcription factor binding sites TFBS . It has been shown that the antibacterial response of human epithelial cells is triggered by at least two distinct