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Báo cáo y học: " Propagated repolarization of simulated action potentials in cardiac muscle and smooth muscle"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: Propagated repolarization of simulated action potentials in cardiac muscle and smooth muscle | BioMed Central Theoretical Biology and Medical Modelling Research Open Access Propagated repolarization of simulated action potentials in cardiac muscle and smooth muscle Nicholas Sperelakis 1 Lakshminarayanan Ramasamy2 and Bijoy Kalloor2 Address 1Dept. of Molecular Cellular Physiology University of Cincinnati College of Medicine Cincinnati OH 45267-0576 USA and 2Dept. of Electrical Computer Engineering and Computer Science University of Cincinnati College of Engineering Cincinnati OH 45219 USA Email Nicholas Sperelakis - spereln@ucmail.uc.edu Lakshminarayanan Ramasamy- lramasamy@gmail.com Bijoy Kalloor - kalloobs@email.uc.edu Corresponding author Published 14 February 2005 Received 30 November 2004 Theoretical Biology and Medical Modelling 2005 2 5 doi 10.1186 1742-4682-2-5 Accepted 14 February 2005 This article is available from http www.tbiomed.cOm content 2 1 5 2005 Sperelakis et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Propagation of repolarization is a phenomenon that occurs in cardiac muscle. We wanted to test whether this phenomenon would also occur in our model of simulated action potentials APs of cardiac muscle CM and smooth muscle SM generated with the PSpice program. Methods A linear chain of 5 cells was used with intracellular stimulation of cell 1 for the antegrade propagation and of cell 5 for the retrograde propagation. The hyperpolarizing stimulus parameters applied for termination of the AP in cell 5 were varied over a wide range in order to generate strength duration S D curves. Because it was not possible to insert a second black box voltage-controlled current source into the basic units representing segments of excitable membrane that would allow the cells to respond to .