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Báo cáo y học: "Data from necropsy studies and in vitro tissue studies lead to a model for allometric scaling of basal metabolic rate"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: Data from necropsy studies and in vitro tissue studies lead to a model for allometric scaling of basal metabolic rate | Theoretical Biology and Medical Modelling BioMed Central Review Open Access Data from necropsy studies and in vitro tissue studies lead to a model for allometric scaling of basal metabolic rate Page R Painter Address Office of Environmental Health Hazard Assessment California Environmental Protection Agency P. O. Box 4010 Sacramento California 95812 USA Email Page R Painter - ppainter@oehha.ca.gov Corresponding author Published 27 September 2005 Received 12 April 2005 Theoretical Biology and Medical Modelling 2005 2 39 doi 10.1186 1742-4682-2-39 Accepted 27 September 2005 This article is available from http www.tbiomed.cOm content 2 1 39 2005 Painter licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background The basal metabolic rate BMR of a mammal of mass M is commonly described by the power function aMp where a and p are constants determined by linear regression of the logarithm of BMR on the logarithm of M i. e. p is the slope and a is the intercept in regression analysis . Since Kleiber s demonstration that for 13 measurements of BMR the logarithm of BMR is closely approximated by a straight line with slope 0.75 it has often been assumed that the value of p is exactly 3 4 Kleiber s law . Results For two large collections of BMR data n 391 and n 619 species the logarithm of BMR is not a linear function of the logarithm of M but is a function with increasing slope as M increases. The increasing slope is explained by a multi-compartment model incorporating three factors 1 scaling of brain tissue and the tissues that form the surface epithelium of the skin and gastrointestinal tract 2 scaling of tissues such as muscle that scale approximately proportionally to body mass and 3 allometric scaling of the metabolic .