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Báo cáo y học: "Genome-wide transcription profiling of human sepsis: a systematic review"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Genome-wide transcription profiling of human sepsis: a systematic review. | Genome-wide transcription profiling of human sepsis a systematic review Tang et al. Tang et al. Critical Care 2010 14 R237 http ccforum.Com content 14 6 R237 29 December 2010 BioMed Central Tang et al. Critical Care 2010 14 R237 http ccforum.eom content 14 6 R237 KS CRITICAL CARE RESEARCH Open Access Genome-wide transcription profiling of human sepsis a systematic review Benjamin M Tang1 2 Stephen J Huang1 Anthony S McLean1 Abstract Introduction Sepsis is thought to be an abnormal inflammatory response to infection. However most clinical trials of drugs that modulate the inflammatory response of sepsis have been unsuccessful. Emerging genomic evidence shows that the host response in sepsis does not conform to a simple hyper-inflammatory hypo-inflammatory model. We therefore synthesized current genomic studies that examined the host response of circulating leukocytes to human sepsis. Methods Electronic searches were performed in Medline and Embase 1987 to October 2010 supplemented by additional searches in multiple microarray data repositories. We included studies that 1 used microarray 2 were performed in humans and 3 investigated the host response mediated by circulating leukocytes. Results We identified 12 cohorts consisting of 784 individuals providing genome-wide expression data in early and late sepsis. Sepsis elicited an immediate activation of pathogen recognition receptors accompanied by an increase in the activities of signal transduction cascades. These changes were consistent across most cohorts. However changes in inflammation related genes were highly variable. Established inflammatory markers such as tumour necrosis factor-a TNF-a interleukin IL -1 or interleukin-10 did not show any consistent pattern in their gene-expression across cohorts. The finding remains the same even after the cohorts were stratified by timing early vs. late sepsis patient groups paediatric vs. adult patients or settings clinical sepsis vs. endotoxemia model . Neither a .