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Báo cáo y học: " Inflammation-induced hepcidin-25 is associated with the development of anemia in septic patients: an observational study"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Inflammation-induced hepcidin-25 is associated with the development of anemia in septic patients: an observational study. | van Eijk et al. Critical Care 2011 15 R9 http ccforum.eom content 15 1 R9 KS CRITICAL CARE RESEARCH Open Access Inflammation-induced hepcidin-25 is associated with the development of anemia in septic patients an observational study I I I r I I m c I 11 1 2 3 4 I z- . t r I IXV r r 2 h ỉ I r I K I V V I 3 4 I r-v p. S-.I- f _ 1 - -J r r I_I fs 1 4 Lucas I van EijK Joyce JC Kroot Mirjam iromp Johannes G van der Hoeven Dorine W SwinKels2 4 Peter PicKKers1 4 Abstract Introduction Anemia is a frequently encountered problem during inflammation. Hepcidin is an interleuKin-6 IL-6 -induced Key modulator of inflammation-associated anemia. Human sepsis is a prototypical inflammatory syndrome often complicated by the development of anemia. However the association between inflammation hepcidin release and anemia has not been demonstrated in this group of patients. Therefore we explored the association between hepcidin and sepsis-associated anemia. Methods 92 consecutive patients were enrolled after presentation on the emergency ward of a university hospital with sepsis indicated by the presence of a proven or suspected infection and 2 extended systemic inflammatory response syndrome SIRS criteria. Blood was drawn at day 1 2 and 3 after admission for the measurement of IL-6 and hepcidin-25. IL-6 levels were correlated with hepcidin concentrations. Hemoglobin levels and data of blood transfusions during 14 days after hospitalisation were retrieved and the rate of hemoglobin decrease was correlated to hepcidin levels. Results 53 men and 39 women with a mean age of 53.3 1.8 yrs were included. Hepcidin levels were highest at admission median IQR 17.9 10.1 to 28.4 nmol l and decreased to normal levels in most patients within 3 days 9.5 3.4 to 17.9 nmol l . Hepcidin levels increased with the number of extended SIRS criteria P 0.0005 . Highest IL-6 levels were measured at admission 125.0 46.3 to 330.0 pg ml and log-transformed IL-6 levels significantly correlated with hepcidin levels .