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Báo cáo y học: "Global transcriptional responses of fission and budding yeast to changes in copper and iron levels: a comparative study"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Global transcriptional responses of fission and budding yeast to changes in copper and iron levels: a comparative study. | Open Access Global transcriptional responses of fission and budding yeast to changes in copper and iron levels a comparative study Gabriella RusticiH Harm van BakelH Daniel H Lackner Frank C Holstege Cisca Wijmenga Jurg Bahler and Alvis Brazma Addresses EMBL Outstation-Hinxton European Bioinformatics Institute Cambridge CB10 1SD UK. Cancer Research UK Fission Yeast Functional Genomics Group Wellcome Trust Sanger Institute Hinxton Cambridge CB10 1HH UK. Complex Genetics Group UMC Utrecht Department of Biomedical Genetics 3584 CG Utrecht The Netherlands. Genomics Laboratory UMC Utrecht Department for Physiological Chemistry 3584 CG Utrecht The Netherlands. Genetics Department University Medical Center Groningen Groningen The Netherlands. H These authors contributed equally to this work. Correspondence Harm van Bakel. Email h.h.m.j.vanbakel@umcutrecht.nl Published 3 May 2007 Genome Biology 2007 8 R73 doi 10.1 186 gb-2007-8-5-r73 The electronic version of this article is the complete one and can be found online at http genomebiology.com 2007 8 5 R73 Received 28 July 2006 Revised 31 January 2007 Accepted 3 May 2007 2007 Rustici et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Recent studies in comparative genomics demonstrate that interspecies comparison represents a powerful tool for identifying both conserved and specialized biologic processes across large evolutionary distances. All cells must adjust to environmental fluctuations in metal levels because levels that are too low or too high can be detrimental. Here we explore the conservation of metal homoeostasis in two distantly related yeasts. Results We examined genome-wide gene expression responses to changing copper and iron levels in budding and