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Báo cáo y học: "Genetic background influences murine prostate gene expression: implications for cancer phenotypes"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Genetic background influences murine prostate gene expression: implications for cancer phenotypes. | Open Access Research Genetic background influences murine prostate gene expression implications for cancer phenotypes Daniella Bianchi-Frias Colin Pritchard Brigham H Mecham Ilsa M Coleman and Peter S Nelson Address Divisions of Human Biology and Clinical Research Fred Hutchinson Cancer Research Center Fairview Avenue Seattle WA 981091024 USA. Correspondence Peter S Nelson. Email pnelson@fhcrc.org Published 18 June 2007 Genome Biology 2007 8 R117 doi l0.ll86 gb-2007-8-6-rl 17 The electronic version of this article is the complete one and can be found online at http genomebiology.com 2007 8 6 R117 Received 5 October 2006 Revised 30 April 2007 Accepted l8 June 2007 2007 Bianchi-Frias et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Cancer of the prostate is influenced by both genetic predisposition and environmental factors. The identification of genes capable of modulating cancer development has the potential to unravel disease heterogeneity and aid diagnostic and prevention strategies. To this end mouse models have been developed to isolate the influences of individual genetic lesions in the context of consistent genotypes and environmental exposures. However the normal prostatic phenotypic variability dictated by a genetic background that is potentially capable of influencing the process of carcinogenesis has not been established. Results In this study we used microarray analysis to quantify transcript levels in the prostates of five commonly studied inbred mouse strains. We applied a multiclass response t-test and determined that approximately 13 932 genes exhibited differential expression range 1.3-190-in any one strain relative to other strains false discovery rate 10 . Expression differences .