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Báo cáo y học: "dentification of novel regulatory factor X (RFX) target genes by"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài:Identification of novel regulatory factor X (RFX) target genes by. | Research Open Access Identification of novel regulatory factor X RFX target genes by comparative genomics in Drosophila species Anne Laurenẹon Raphaelle Dubruille n Evgeni Efimenko Guillaume Grenier Ryan Bissett Elisabeth Cortier Vivien Rolland Peter Swoboda and Bénédicte Durand ỷ Addresses Université de Lyon Lyon F-69003 France. Université Lyon 1 CNRS UMR5534 Centre de Génétique Moléculaire et Cellulaire Villeurbanne F-69622 France. University of Massachusetts Medical School Department of Neurobiology Worcester MA 01605 USA. Karolinska Institute Department of Biosciences and Nutrition Sodertorn University College School of Life Sciences S-14189 Huddinge Sweden. University of Glasgow Glasgow Biomedical Research Centre Wellcome Centre for Molecular Parasitology and Infection and Immunity Glasgow G12 8TA UK. Correspondence Anne Laurenẹon. Email laurencon@cgmc.univ-lyon1.fr Published 17 September 2007 Genome Biology 2007 8 RI95 doi I0.II86 gb-2007-8-9-rI 95 The electronic version of this article is the complete one and can be found online at http genomebiology.com 2007 8 9 RI95 Received 23 July 2007 Revised 14 September 2007 Accepted l7 September 2007 2007 Laurenẹon et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Regulatory factor X RFX transcription factors play a key role in ciliary assembly in nematode Drosophila and mouse. Using the tremendous advantages of comparative genomics in closely related species we identified novel genes regulated by dRFX in Drosophila. Results We first demonstrate that a subset of known ciliary genes in Caenorhabditis elegans and Drosophila are regulated by dRFX and have a conserved RFX binding site X-box in their promoters in two highly divergent Drosophila species. We