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Báo cáo y học: "Comparative genomic analysis of fungal genomes reveals intron-rich ancestors"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Comparative genomic analysis of fungal genomes reveals intron-rich ancestors. | Open Access Research Comparative genomic analysis of fungal genomes reveals intron-rich ancestors Jason E Stajich Fred S Dietrich and Scott W Roy Addresses Department of Molecular Genetics and Microbiology Center for Genome Technology Institute for Genome Science and Policy Duke University Durham NC 27710 USA. tMiller Institute for Basic Research and Department of Plant and Microbial Biology 111 Koshland Hall 3102 University of California Berkeley CA 94720-3102 USA. National Center for Biotechnology Information National Library of Medicine National Institutes of Health 8600 Rockville Pike Bethesda MD 20894 USA. Correspondence Jason E Stajich. Email jason_stajich@berkeley.edu Scott W Roy. Email royscott@ncbi.nlm.nih.gov Published 19 October 2007 Genome Biology 2007 8 R223 doi 10.1186 gb-2007-8- l0-r223 The electronic version of this article is the complete one and can be found online at http genomebiology.com 2007 8 10 R223 Received 19 December 2006 Revised 12 October 2007 Accepted 19 October 2007 2007 Stajich et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Eukaryotic protein-coding genes are interrupted by spliceosomal introns which are removed from transcripts before protein translation. Many facets of spliceosomal intron evolution including age mechanisms of origins the role of natural selection and the causes of the vast differences in intron number between eukaryotic species remain debated. Genome sequencing and comparative analysis has made possible whole genome analysis of intron evolution to address these questions. Results We analyzed intron positions in 1 161 sets of orthologous genes across 25 eukaryotic species. We find strong support for an intron-rich fungus-animal ancestor with more