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Báo cáo y học: "The global landscape of sequence diversity"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: The global landscape of sequence diversity. | Open Access The global landscape of sequence diversity José Manuel Peregrín-Ãlvarez Ỷ and John Parkinson Addresses Molecular Structure and Function Hospital for Sick Children 555 University Avenue Toronto ON M5G 1X8 Canada. Departments of Biochemistry and Molecular Genetics 1 King s College Circle University of Toronto Toronto ON M5S 1A1 Canada. Correspondence John Parkinson. Email jparkin@sickkids.ca Published 8 November 2007 Genome Biology 2007 8 R238 doi l0.ll86 gb-2007-8-ll-r238 The electronic version of this article is the complete one and can be found online at http genomebiology.com 2007 8 ll R238 Received 25 May 2007 Revised 18 October 2007 Accepted 8 November 2007 2007 Peregrín-Álvarez and Parkinson licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Systematic comparisons between genomic sequence datasets have revealed a wide spectrum of sequence specificity from sequences that are highly conserved to those that are specific to individual species. Due to the limited number of fully sequenced eukaryotic genomes analyses of this spectrum have largely focused on prokaryotes. Combining existing genomic datasets with the partial genomes of 193 eukaryotes derived from collections of expressed sequence tags we performed a quantitative analysis of the sequence specificity spectrum to provide a global view of the origins and extent of sequence diversity across the three domains of life. Results Comparisons with prokaryotic datasets reveal a greater genetic diversity within eukaryotes that may be related to differences in modes of genetic inheritance. Mapping this diversity within a phylogenetic framework revealed that the majority of sequences are either highly conserved or specific to the species or taxon