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Báo cáo y học: " Horizontal gene transfer and the evolution of transcriptional regulation in Escherichia col"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Horizontal gene transfer and the evolution of transcriptional regulation in Escherichia coli. | Open Access Research Horizontal gene transfer and the evolution of transcriptional regulation in Escherichia coli Morgan N Price Paramvir S Dehal and Adam P Arkin 1 Addresses Physical Biosciences Division Lawrence Berkeley National Laboratory 1 Cyclotron Road Mailstop 977-152 Berkeley California 94720 USA. Virtual Institute of Microbial Stress and Survival Lawrence Berkeley National Laboratory 1 Cyclotron Road Mailstop 977-152 Berkeley California 94720 USA. Department of Bioengineering 1 Cyclotron Road Mailstop 977-152 University of California Berkeley 94720 California USA. Correspondence Morgan N Price. Email morgannprice@yahoo.com Published 7 January 2008 Genome Biology 2008 9 R4 doi 10.1186 gb-2008-9-1-r4 The electronic version of this article is the complete one and can be found online at http genomebiology.com 2008 9 1 R4 Received 4 August 2007 Revised 6 November 2007 Accepted 7 January 2008 2008 Price et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Most bacterial genes were acquired by horizontal gene transfer from other bacteria instead of being inherited by continuous vertical descent from an ancient ancestor. To understand how the regulation of these acquired genes evolved we examined the evolutionary histories of transcription factors and of regulatory interactions from the model bacterium Escherichia coli K12. Results Although most transcription factors have paralogs these usually arose by horizontal gene transfer rather than by duplication within the E. coli lineage as previously believed. In general most neighbor regulators - regulators that are adjacent to genes that they regulate - were acquired by horizontal gene transfer whereas most global regulators evolved vertically within the