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Báo cáo y học: "The AAA+ superfamily of functionally diverse proteins"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: The AAA+ superfamily of functionally diverse proteins. | Review The AAA superfamily of functionally diverse proteins Jamie Snider Guillaume Thibault and Walid A Houry Address Department of Biochemistry University of Toronto Medical Sciences Building 1 King s College Circle Toronto Ontario M5S 1A8 Canada. These authors contributed equally to this work Correspondence Walid A Houry. Email walid.houry@utoronto.ca Published 30 April 2008 Genome Biology 2008 9 216 doi 10.1186 gb-2008-9-4-216 The electronic version of this article is the complete one and can be found online at http genomebiology.com 2008 9M 216 2008 BioMed Central Ltd Summary The AAA superfamily is a large and functionally diverse superfamily of NTPases that are characterized by a conserved nucleotide-binding and catalytic module the AAA module. Members are involved in an astonishing range of different cellular processes attaining this functional diversity through additions of structural motifs and modifications to the core AAA module. The ATPases associated with diverse cellular activities AAA proteins form a large and diverse superfamily found in all organisms. These proteins typically assemble into hexameric ring complexes that are involved in the energydependent remodeling of macromolecules 1 . Members of the AAA superfamily contain a highly conserved ATPase module of 200-250 amino acids which includes an p core domain where the Walker A and B motifs of the P-loop NTPases are found 2-4 . AAA proteins are involved in a wide variety of different functions in which the energy extracted from ATP hydrolysis is used in molecular remodeling events. They are involved in processes as diverse as protein unfolding and degradation peroxisome biogenesis bacteriochlorophyll biosynthesis and DNA recombination replication and repair. AAA proteins include the molecular motor dynein helicases involved in DNA replication metal chelatases and proteasome-associa-ted proteins. As a consequence of their diverse functions AAA proteins can be found in most subcellular compartments