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Báo cáo y học: " Sequencing the regulatory genome"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Sequencing the regulatory genome. | Meeting report Sequencing the regulatory genome Stein Aerts and Stefanie Butland Addresses Laboratory of Neurogenetics Department of Molecular and Developmental Genetics VIB Leuven B-3000 Belgium. fCentre for Molecular Medicine and Therapeutics CFRI University of British Columbia Vancouver V5Z 4H4 Canada. Correspondence Stefanie Butland. Email butland@cmmt.ubc.ca Published 19 June 2008 Genome Biology 2008 9 313 doi 10.1186 gb-2008-9-6-313 The electronic version of this article is the complete one and can be found online at http genomebiology.com 2008 9 6 313 2008 BioMed Central Ltd A report on the Cold Spring Harbor Laboratory meeting Systems Biology Global Regulation of Gene Expression Cold Spring Harbor USA 27-30 March 2008. The line between the biological and computational research communities has disappeared in the field of gene regulation. The group of regulatory biology researchers represented at the recent meeting at Cold Spring Harbor on systems biology shares the same goal develop and apply experimental and computational technologies to decipher the genomic regulatory code and the gene regulatory networks that are the driving forces of development and evolution. As in previous years important gaps in solving the complex problem of gene regulation were bridged. This year featured the emerging massively parallel sequencing technologies which are now being applied to every conceivable step in the gene regulation process from gene annotation and alternative splicing to transcription factor binding and chromatin structure. Topics covered at the meeting ranged widely and in this report we give our impressions of some highlights in two dominant themes gene regulation in a nuclear context and transcription factor binding specificity. Genome geography in three dimensions When transcription factors are reading the genomic regulatory code to determine the complement of active genes in a cell at a given time they can be aided guided or obstructed by the chromatin they