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Báo cáo sinh học: " Genomic selection of purebreds for crossbred performance"

Tuyển tập các báo cáo nghiên cứu về sinh học được đăng trên tạp chí sinh học quốc tế đề tài: Genomic selection of purebreds for crossbred performance | Genetics Selection Evolution BioMed Central Research Genomic selection of purebreds for crossbred performance Noelia Ibanez-Escriche1 Rohan L Fernando2 Ali Toosi2 and Jack CM Dekkers 2 Address 1Genètica i Millora Animal- Centre IRTA Lleida 25198 Lleida Spain and 2Department of Animal Science Iowa State University Ames 50011-3150 USA Email Noelia Ibánẽz-Escriche - noelia.ibanez@irta.es Rohan L Fernando - rohan@iastate.edu AliToosi - atoosi@iastate.edu Jack CM Dekkers - jdekkers@iastate.edu Corresponding author Open Access Published 15 January 2009 Received 14 January 2009 Genetics Selection Evolution 2009 41 12 doi l0.ll86 l297-9686-4l-l2 Accepted 15 January 2009 This article is available from http www.gsejournal.Org content 4l l l2 2009 Ibánẽz-Escriche et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background One of the main limitations of many livestock breeding programs is that selection is in pure breeds housed in high-health environments but the aim is to improve crossbred performance under field conditions. Genomic selection GS using high-density genotyping could be used to address this. However in crossbred populations l effects of SNPs may be breed specific and 2 linkage disequilibrium may not be restricted to markers that are tightly linked to the QTL. In this study we apply GS to select for commercial crossbred performance and compare a model with breed-specific effects of SNP alleles BSAM to a model where SNP effects are assumed the same across breeds ASGM . The impact of breed relatedness generations since separation size of the population used for training and marker density were evaluated. Trait phenotype was controlled by 30 QTL and had a heritability of 0.30 for crossbred individuals. A .