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Báo cáo y học: "Genomic and proteomic adaptations to growth at high temperature"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: Genomic and proteomic adaptations to growth at high temperature. | Opinion Genomic and proteomic adaptations to growth at high temperature Donal A Hickey and Gregory AC Singer Addresses Department of Biology Concordia University 7141 Sherbrooke Street Montreal Quebec H4B 1R6 Canada. Human Cancer Genetics Program Comprehensive Cancer Center Department of Molecular Virology Immunology and Medical Genetics The Ohio State University Columbus OH 43210 USA. Correspondence Donal A Hickey. E-mail dhickey@alcor.concordia.ca Published 30 September 2004 Genome Biology 2004 5 117 The electronic version of this article is the complete one and can be found online at http genomebiology.com 2004 5 l0 ll7 2004 BioMed Central Ltd Abstract Most positively selected mutations cause changes in metabolism resulting in a better-adapted phenotype. But as well as acting on the information content of genes natural selection may also act directly on nucleic acid and protein molecules. We review the evidence for direct temperaturedependent natural selection acting on genomes transcriptomes and proteomes. What s so special about adaptation to growth at high temperature Variations in environmental temperature represent an obvious and easily quantifiable form of environmental heterogeneity. Biologists have long been aware of a host of behavioral morphological and physiological adaptations to this environmental variable. Recently the accumulation of genomic data has led to an interest in another type of temperature adaptation. Specifically we would like to know whether the genomes themselves - along with their encoded proteomes -are subject to predictable temperature-dependent patterns of molecular evolution. While variations in environmental temperature share many of the characteristics of other environmental variables temperature is special because of its pervasiveness it can penetrate physical barriers and can have dramatic effects on the structure of virtually all macromolecules. And given that temperature variation affects all levels of biological adaptation