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Báo cáo y học: "A comprehensive transcript index of the human genome generated using microarrays and computational approaches"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: A comprehensive transcript index of the human genome generated using microarrays and computational approaches. | Research Open Access A comprehensive transcript index of the human genome generated using microarrays and computational approaches Eric E Schadt Stephen W Edwards Debraj GuhaThakurta Dan Holder Lisa Ying Vladimir Svetnik Amy Leonardson Kyle W Hart Archie Russell Guoya Li Guy Cavet John Castle Paul McDonagh Zhengyan Kan Ronghua Chen Andrew Kasarskis Mihai Margarint Ramon M Caceres Jason M Johnson Christopher D Armour Philip W Garrett-Engele Nicholas F Tsinoremas and Daniel D Shoemaker Addresses Rosetta Inpharmatics LLC 12040 115th Avenue NE Kirkland WA 98034 USA. tMerck Research Laboratories W42-213 Sumneytown Pike POB 4 Westpoint PA 19846 USA. Rally Scientific 41 Fayette Street Suite 1 Watertown MA 02472 USA. Amgen Inc 1201 Amgen Court W Seattle WA 98119 USA. Tfhe Scripps Research Institute Jupiter FL 33458 USA. K These authors contributed equally to this work. Correspondence Eric E Schadt. E-mail eric_schadt@merck.com. Daniel D Shoemaker. E-mail shoemakd@stanfordalumni.org Received 4 May 2004 Revised 7 July 2004 Accepted 16 August 2004 Published 23 September 2004 Genome Biology 2004 5 R73 The electronic version of this article is the complete one and can be found online at http genomebiology.com 2004A5 10 R73 2004 Schadt et al. licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. I II ell III I III Abstract Background Computational and microarray-based experimental approaches were used to generate a comprehensive transcript index for the human genome. Oligonucleotide probes designed from approximately 50 000 known and predicted transcript sequences from the human genome were used to survey transcription from a diverse set of 60 tissues and cell lines using inkjet microarrays. Further expression activity over at least six .