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Báo cáo y học: "Biochip sensors for the rapid and sensitive detection of viral disease"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Wertheim cung cấp cho các bạn kiến thức về ngành y đề tài: Biochip sensors for the rapid and sensitive detection of viral disease. | Opinion Biochip sensors for the rapid and sensitive detection of viral disease Andrew D Livingston Colin J Campbell Edward K Wagner and Peter Ghazal Addresses Scottish Centre for Genomic Technology and Informatics College of Medicine University of Edinburgh Edinburgh EH16 4SB UK. Department of Molecular Biology and Biochemistry and Center for Virus Research University of California Irvine CA 92697 USA. Correspondence Andrew Livingston A.D.Livingston@sms.ed.ac.uk Published 26 May 2005 Genome Biology 2005 6 112 doi 10.1186 gb-2005-6-6-112 The electronic version of this article is the complete one and can be found online at http genomebiology.com 2005 6 6 112 2005 BioMed Central Ltd Abstract Recent advances in DNA and protein microarray methodology and the emerging technology of cellbased sensors have massively increased the speed and sensitivity with which we can detect viral infections. The advantages of the multi-parameter microarray technologies could be combined with the speed and sensitivity of cell-based systems to give cell-omic sensors. In 2003 China took measures to contain an outbreak of flulike illness 1 when the same disease which came to be called severe acute respiratory syndrome SARS began to appear in other countries the World Health Organization initiated a global response 2 . This incident highlighted on a world stage the need for rapid and accurate techniques for pathogen identification. Failure to have such tools puts lives at risk by severely hampering containment and effective vaccination strategies. Over the past few decades the identification and characterization of infectious agents has been refined and improved resulting in highly sensitive and precise methodologies that will soon be able to measure individual molecules. This sensitivity comes at a cost however in terms of time complexity of assay and robustness of measurements and this can have a negative impact on patient care. The prognosis for the majority of serious infections is vastly