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Báo cáo y học: "The Dictyostelium genome: the private life of a social model revealed"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Wertheim cung cấp cho các bạn kiến thức về ngành y đề tài: The Dictyostelium genome: the private life of a social model revealed? | Minireview The Dictyostelium genome the private life of a social model revealed Robert Insall Address School of Biosciences University of Birmingham Birmingham B15 2TT UK. E-mail R.H.Insall@bham.ac.uk Published 9 May 2005 Genome Biology 2005 6 222 doi l0.ll86 gb-2005-6-6-222 The electronic version of this article is the complete one and can be found online at http genomebiology.com 2005 6 6 222 2005 BioMed Central Ltd Abstract The complete genome sequence of Dictyostelium a widely studied social amoeba reveals unexpected complexities in genome structure and cell motility and signaling most notably the presence of a large number of G-protein-coupled receptors not previously found outside animals and the absence of receptor tyrosine kinases. The social amoeba Dictyostelium discoideum is widely studied in particular because aspects of its lifestyle are especially suitable for experiments that are difficult in other organisms. It has an intriguing way of becoming multicellular following growth as unicellular amoebae. Starving cells stream together by chemotaxis towards autocrine signals and form aggregates that can contain millions of cells. These differentiate into complex fruiting bodies which somewhat resemble those of fungi. This behavior makes Dictyostelium an excellent organism for studying chemotaxis and movement as well as the cell-cell interactions and differentiation required to make an ordered structure out of a pile of cells. It has also resulted in an unfortunate tendency seen in a thousand reviews and grant applications to call Dictyostelium a simple model organism. In truth Dictyostelium species are highly adapted and extremely successful and can be found in almost any soil anywhere on the globe. They eat some organisms mostly bacteria and try not to be eaten by others such as nematodes . There is no room for simplicity in this lifestyle and the newly published genome sequence 1 reveals an organism that is complex and highly evolved even if a number of .