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Báo cáo y học: "Evidence for a second class of S-adenosylmethionine riboswitches and other regulatory RNA motifs in alpha-proteobacteria"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Wertheim cung cấp cho các bạn kiến thức về ngành y đề tài: Evidence for a second class of S-adenosylmethionine riboswitches and other regulatory RNA motifs in alpha-proteobacteria. | Research Open Access Evidence for a second class of S-adenosylmethionine riboswitches and other regulatory RNA motifs in alpha-proteobacteria Keith A Corbino Jeffrey E Barrick Jinsoo Lim Rudiger Welz Brian J Tucker Izabela Puskarz Maumita Mandal Noam D Rudnick and Ronald R Breaker Addresses Department of Molecular Cellular and Developmental Biology Yale University P.O. Box 208103 New Haven CT 06520-8103 USA. Department of Molecular Biophysics and Biochemistry Yale University P.O. Box 208103 New Haven CT 06520-8103 USA. Department of Chemistry Yale University P.O. Box 208103 New Haven CT 06520-8103 USA. Department of Physics University of California Berkeley CA 94720-7200 USA. Correspondence Ronald RBreaker. E-mail ronald.breaker@yale.edu Published I August 2005 Genome Biology 2005 6 R70 doi I0.I I86 gb-2005-6-8-r70 The electronic version of this article is the complete one and can be found online at http genomebiology.com 2005 6 8 R70 Received 28 April 2005 Revised 15 June 2005 Accepted I July 2005 2005 Corbino et al. licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Riboswitches are RNA elements in the 5 untranslated leaders of bacterial mRNAs that directly sense the levels of specific metabolites with a structurally conserved aptamer domain to regulate expression of downstream genes. Riboswitches are most common in the genomes of low GC Gram-positive bacteria for example Bacillus subtilis contains examples of all known riboswitches and some riboswitch classes seem to be restricted to this group. Results We used comparative sequence analysis and structural probing to identify five RNA elements serC speF suhB ybhL and metA that reside in the intergenic regions of Agrobacterium tumefaciens and many other .