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Báo cáo y học: "Understanding embryonic development: from screens to genes"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Wertheim cung cấp cho các bạn kiến thức về ngành y đề tài: Understanding embryonic development: from screens to genes. | Meeting report Understanding embryonic development from screens to genes Lisa A Taneyhill Address Division of Biology California Institute of Technology Pasadena CA 91125 USA. E-mail ltaney@caltech.edu Published 24 November 2005 Genome Biology 2005 6 359 doi l0.ll86 gb-2005-6-l2-359 The electronic version of this article is the complete one and can be found online at http genomebiology.com 2005 6 12 359 2005 BioMed Central Ltd A report on the 64th Annual Meeting of the Society for Developmental Biology San Francisco USA 27 July-l August 2005. The elucidation of the complete genome sequences of various model organisms in conjunction with the development of new screening methods provides a type of functional genomics that has been unavailable to developmental biologists in the past. The collaboration between novel computational and molecular biological techniques and traditional embryology was evident in the outstanding research presented at the annual meeting of the Society for Developmental Biology held in San Francisco this summer. The underlying theme of the meeting was how a partnering between different disciplines can be extremely fruitful in enabling both gene discovery and the understanding of how genes work in concert to carry out developmental processes. Highly pertinent to this theme were discussions about RNA interference RNAi screening. Julie Ahringer Wellcome Trust Cancer Research UK Gurdon Institute University of Cambridge UK discussed the work in her laboratory that uses genome-wide RNAi screening to understand the molecular basis of cell polarity in the nematode Caenorhabditis elegans in which RNAi is readily achieved by feeding worms with bacteria containing DNA sequences encoding interfering RNAs. Using an RNAi library consisting of 16 757 such bacterial strains covering 86 of the C. elegans genome Ahringer s group has identified 1 722 genes with an RNAi phenotype 1 200 of which are novel by performing a dissecting microscope screen for worms .