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Báo cáo y học: "Unraveling prion structures and biological"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Minireview cung cấp cho các bạn kiến thức về ngành y đề tài: Unraveling prion structures and biological | Meeting report Unraveling prion structures and biological functions Michael Ter-Avanesyan Irina Derkatch Ilia Baskakov and Vitaly Kushnirov Addresses Cardiology Research Center 3rd Cherepkovskaya Street 15A 121552 Moscow Russia. fNew York University School of Medicine Department of Microbiology 550 First Avenue New York NY 10016 USA. University of Maryland Biotechnology Institute 725 West Lombard Street Baltimore MD 21201 USA. Correspondence Michael Ter-Avanesyan. E-mail mdter@cardio.ru Published 3 January 2006 Genome Biology 2005 6 366 doi l0.ll86 gb-2005-6-l3-366 The electronic version of this article is the complete one and can be found online at http genomebiology.com 2005 6 13 366 2005 BioMed Central Ltd A report on a Joint Cold Spring Harbor Laboratory Wellcome Trust Conference on Prion Biology Hinxton UK 7-11 September 2005. While most recent prion meetings have focused on either mammals or fungi the conference on prion biology held near Cambridge this September stood out as an attempt to represent research on mammalian and fungal prions equally in order to provoke discussion on fundamental questions of prion structure biogenesis variability and biological role. Prions of lower eukaryotes Over the past decade several infective proteins or prions have been discovered in genetically tractable lower eukaryotes where they act like cytoplasmically inherited genetic determinants. The opening talk of the meeting was delivered by Reed Wickner National Institutes of Health Bethesda USA who was the first to suggest 11 years ago that the non-chromosomal genetic determinants known as URE3 and PSI in the yeast Saccharomyces cerevisiae were in fact prion proteins enclosure in square brackets is the conventional nomenclature for cytoplasmically inherited genetic determinants in fungi . The proteins that correspond to URE3 and PSI regulator of nitrogen metabolism Ure2 and translation termination factor Sup35 respectively have carboxy-terminal domains that carry out a .