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Báo cáo y học: "Lipids join the post-genomic era"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Minireview cung cấp cho các bạn kiến thức về ngành y đề tài: Lipids join the post-genomic era. | Meeting report Lipids join the post-genomic era Reinhard Bauer and Axel Imhof Addresses Department of Molecular Developmental Biology LIMES Institute University of Bonn Poppelsdorfer Schloss 53115 Bonn Germany. fHistone Modifications Group Adolf-Butenandt Institut University of Munich Schillerstrasse 44 80336 Munich Germany. Correspondence Axel Imhof. E-mail imhof@lmu.de Published 31 October 2006 Genome Biology 2006 7 330 doi l0.ll86 gb-2006-7-l0-330 The electronic version of this article is the complete one and can be found online at http genomebiology.com 2006 7 10 330 2006 BioMed Central Ltd A report of the meeting From Proteomics to Lipidomics -Basics Advances and Applications Bonn Germany 30 June-l July 2006. The global analysis of biomolecules such as proteins lipids and carbohydrates within a tissue cell or organelle under specific physiological situations is a major challenge of the post-genomic era. Experts from the fields of proteomics lipidomics and metabolomics discussed this challenge at a recent meeting on these topics in Bonn. Our ability to determine large numbers of proteins from a biological sample has dramatically increased through the development of soft-ionization techniques and the growing availability of state-of-the-art mass spectrometers even in non-specialist laboratories. One of the pioneers in applying mass spectrometry to biomolecules Franz Hillenkamp University of Munster Germany gave an excellent introduction to the basic mechanisms of matrix-assisted laser desorption ionization MALDI . He discussed the use of MALDI-MS for the imaging of biological tissue and proposed the use of infrared-laser rather than the more commonly used UV-lasers for this aim. Using this different setting the critical matrix preparation step can be avoided and analytes can be directly ionized thereby preventing artificial results. Boris Macek Max Planck Institute of Biochemistry Munich Germany gave an introduction to electrospray-ionization ESI mass .