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Báo cáo y học: " Boosting with stumps for predicting transcription start sites"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Minireview cung cấp cho các bạn kiến thức về ngành y đề tài: Boosting with stumps for predicting transcription start sites. | Open Access Method Boosting with stumps for predicting transcription start sites Xiaoyue Zhao Zhenyu Xuan and Michael Q Zhang Address Cold Spring Harbor Laboratory 1 Bungtown Road Cold Spring Harbor New York 11724 USA. Correspondence Michael Q Zhang. Email mzhang@cshl.edu Published 2 February 2007 Genome Biology 2007 8 R17 doi 10.1186 gb-2007-8-2-r17 The electronic version of this article is the complete one and can be found online at http genomebiology.com 2007 8 2 R17 Received 3 October 2006 Revised 1 December 2006 Accepted 2 February 2007 2007 Zhao et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Promoter prediction is a difficult but important problem in gene finding and it is critical for elucidating the regulation of gene expression. We introduce a new promoter prediction program CoreBoost which applies a boosting technique with stumps to select important small-scale as well as large-scale features. CoreBoost improves greatly on locating transcription start sites. We also demonstrate that by further utilizing some tissue-specific information better accuracy can be achieved. Background Initiation of transcription of protein coding genes is a very important step in the regulation of gene expression. This process starts with the assembly of the RNA polymerase II Pol II preinitiation complex at the promoter. The term promoter commonly refers to the DNA region that is immediately upstream of a gene and that is required to control and regulate the transcription initiation of the gene. A core promoter with a length of about 100 base pairs bp is centered around the transcription start site TSS and a proximal promoter contains several hundred bases immediately upstream of the core promoter. The main .