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Báo cáo y học: " Whole genome transcriptome polymorphisms in Arabidopsis thaliana"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Minireview cung cấp cho các bạn kiến thức về ngành y đề tài: Whole genome transcriptome polymorphisms in Arabidopsis thaliana. | Open Access Method Whole genome transcriptome polymorphisms in Arabidopsis thaliana Xu ZhangH Jake K ByrnesH Thomas S Gal Wen-Hsiung Li and Justin O Borevitz Address Department of Ecology and Evolution University of Chicago 1101 E. 57th Street Chicago IL 60637 USA. H These authors contributed equally to this work. Correspondence Justin O Borevitz. Email borevitz@uchicago.edu Published 24 November 2008 Genome Biology 2008 9 R165 doi l0.ll86 gb-2008-9- 11-r165 The electronic version of this article is the complete one and can be found online at http genomebiology.com 2008 9 11 R165 Received 30 August 2008 Revised 1 November 2008 Accepted 24 November 2008 2008 Zhang et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Whole genome tiling arrays are a key tool for profiling global genetic and expression variation. In this study we present our methods for detecting transcript level variation splicing variation and allele specific expression in Arabidopsis thaliana. We also developed a generalized hidden Markov model for profiling transcribed fragment variation de novo. Our study demonstrates that whole genome tiling arrays are a powerful platform for dissecting natural transcriptome variation at multidimension and high resolution. Background Natural gene expression variation represents perturbations in the cellular network underlying morphological and physiological diversity. It reveals altered signaling pathways that may include early events responsible for phenotypic variation. Gene expression phenotypes are complex traits that map to genetic loci acting in cis and or trans 1-5 . Trans-acting loci affect expression of both alleles of the downstream gene while cis-acting loci represent genetic polymorphisms in the .