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Báo cáo y học: " Co-evolutionary networks of genes and cellular processes across fungal species"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Minireview cung cấp cho các bạn kiến thức về ngành y đề tài: Co-evolutionary networks of genes and cellular processes across fungal species | Open Access Co-evolutionary networks of genes and cellular processes across fungal species Tamir Tuller Martin Kupieđ and Eytan Ruppin Addresses School of Computer Sciences Tel Aviv University Ramat Aviv 69978 Israel. Department of Molecular Microbiology and Biotechnology Tel Aviv University Ramat Aviv 69978 Israel. School of Medicine Tel Aviv University Ramat Aviv 69978 Israel. Correspondence TamirTuller. Email tamirtul@post.tau.ac.il. Martin Kupiec. Email martin@post.tau.ac.il Published 5 May 2009 Genome Biology 2009 10 R48 doi 10.1186 gb-2009- l0-5-r48 The electronic version of this article is the complete one and can be found online at http genomebiology.com 2009 10 5 R48 Received 24 February 2009 Revised 24 February 2009 Accepted 5 May 2009 2009 Tuller et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background The introduction of measures such as evolutionary rate and propensity for gene loss have significantly advanced our knowledge of the evolutionary history and selection forces acting upon individual genes and cellular processes. Results We present two new measures the relative evolutionary rate pattern rERP which records the relative evolutionary rates of conserved genes across the different branches of a species phylogenetic tree and the copy number pattern CNP which quantifies the rate of gene loss of less conserved genes. Together these measures yield a high-resolution study of the coevolution of genes in 9 fungal species spanning 3 540 sets of orthologs. We find that the evolutionary tempo of conserved genes varies in different evolutionary periods. The co-evolution of genes Gene Ontology categories exhibits a significant correlation with their functional distance in the Gene Ontology hierarchy