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Báo cáo y học: "Dosage compensation on the active X chromosome minimizes transcriptional noise of X-linked genes in mammals"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Minireview cung cấp cho các bạn kiến thức về ngành y đề tài: Dosage compensation on the active X chromosome minimizes transcriptional noise of X-linked genes in mammals. | Open Access Researc h Dosage compensation on the active X chromosome minimizes transcriptional noise of X-linked genes in mammals Shanye Yin Ping Wang Wenjun Deng Hancheng Zheng Landian Hu Laurence D Hurst and Xiangyin Kong Addresses The Key Laboratory of Stem Cell Biology Institute of Health Sciences Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai JiaoTong University School of Medicine South Chongqing Road Shanghai 200025 PR China. State Key Laboratory of Medical Genomics Ruijin Hospital Shanghai Jiaotong University Rui Jin Road II Shanghai 200025 PR China. Department of Biology and Biochemistry University of Bath Bath BA2 7AY UK. Correspondence Laurence D Hurst. Email l.d.hurst@bath.ac.uk. Xiangyin Kong. Email xykong@sibs.ac.cn Published 13 July 2009 Genome Biology 2009 10 R74 doi 10.1186 gb-2009- 10-7-r74 The electronic version of this article is the complete one and can be found online at http genomebiology.com 2009 10 7 R74 Received 22 April 2009 Revised 13 June 2009 Accepted 13 July 2009 2009 Yin et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Theory predicts that haploid-expressed genes should have noisier expression than comparable diploid-expressed ones with the same expression level. However in mammals there are several classes of gene that are monoallelically expressed including X-linked genes imprinted genes and some other autosomal genes. Does it follow that the evolution of X chromosomes in eukaryotes comes at the cost of increased transcriptional noise in the heterogametic sex Moreover is escaping X-inactivation in mammalian females associated with an increase in transcriptional variation To address these questions we analyze gene expression .