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Dermatology therapy essentials - part 6

Định nghĩa khối u có nguồn gốc nội mô, liên quan đến da, bề mặt niêm mạc, và Bệnh sinh cơ quan nội tạng không rõ ràng liệu một bệnh tăng sản hoặc khối u thực sự; Herpes hominis virus 8 (HHV-8) liên quan đến tất cả các phân nhóm | K K-M syndrome Kasabach-Merritt syndrome I------------------- Kaposi s sarcoma Synonym s Kaposi sarcoma multiple idiopathic hemorrhagic sarcoma Kaltostat Alginates Kaposi sarcoma Kaposi s sarcoma Kaposi varicelliform eruption Eczema herpeticum Kaposi s sarcoma. Violaceous papules and plaques on the lower extremity Definition Neoplasm of endothelial origin involving the skin mucosal surfaces and internal organs Pathogenesis Unclear whether a hyperplastic disease or a true neoplasm Herpes hominis virus-8 HHV-8 linked to all subtypes co-factors immunosuppression genetics country of residence and male sex Kaposi s dermatosis Xeroderma pigmentosum Clinical manifestation Classic subtype usually affects older men of Mediterranean or eastern European 322 Kaposi s sarcoma-like granuloma backgrounds sometimes arises in chronically edematous extremities violaceous patches plaques or nodules on the lower extremities which can be painful and can ulcerate African endemic subtype primarily affects boys and men appears same as classic subtype or in a more deadly form involving bones and lymph system Iatrogenic subtype seen in kidney and liver transplant patients on immunosuppressive drugs usually regresses after immunosuppressive drug stopped AIDS-related subtype lesions often appear on the upper body including the oral cavity head neck back and in viscera begin as discrete red or purple patches that are bilaterally symmetric and initially tend to involve the lower extremities patches become elevated evolving into nodules and plaques sometimes arise as a large infiltrating mass or as multiple cone-shaped friable tumors Differential diagnosis Pyogenic granuloma tufted angioma melanocytic nevus melanoma cavernous hemangioma angiokeratoma metastasis myofibromatoma arteriovenous malformations Therapy None indicated for indolent skin tumors in elderly patients localized disease cryotherapy radiation therapy surgical excision or laser ablation intralesional vinblastine chemotherapy .