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Handbook of clinical drug data - part 2

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Didanosine (dideoxyinosine [ddI) là một nucleoside purine trải qua quá trình trao đổi chất phức tạp trong cơ thể sống dideoxyadenosine (DDA), cuối cùng trải qua quá trình trao đổi chất là một hình thức hoạt động triphosphorylated (ddATP). Kết hợp ddATP vào DNA của virus dẫn đến chấm dứt chuỗi | 102 Antimicrobial Drugs DIDANOSINE Videx Videx EC Pharmacology. Didanosine dideoxyinosine ddI is a purine nucleoside that undergoes complex metabolism in vivo to dideoxyadenosine ddA which ultimately undergoes metabolism to an active triphosphorylated form ddATP . Incorporation of ddATP into viral DNA leads to chain termination and ddATP is a competitive inhibitor of HiV reverse transcriptase which further contributes to the interference of HIV replication.95 96 Administration and Adult Dosage. PO for HIV infection tablets or solution 60 kg 200 mg as 2 tablets q 12 hr or 400 mg day as 2 tablets or 250 mg as powder q 12 hr 60 kg 125 mg as 2 tablets q 12 hr or 250 mg day as 2 tablets or 167 mg as powder q 12 hr. Take each dose as 2 whole not partial tablets to provide adequate buffering. PO for HIV infection EC capsules same dosage as above but as a single daily dose. Special Populations. Pediatric Dosage. PO for HIV infection 120 mg m2bid. Geriatric Dosage. Same as adult dosage but not studied in this population. Other Conditions. Consider dosage reduction in patients with renal or hepatic impairment. Tablets or solution Clcr 30-59 mL min 60 kg 200 mg day as 2 tablets or EC capsules or 100 mg as 2 tablets bid 60 kg 150 mg day as 2 tablets 75 mg as 2 tablets bid or 125 mg day as EC capsules . Clcr 1029 mL min 60 kg 150 mg day as 2 tablets or 125 mg day as EC capsules 60 kg 100 mg day as 2 tablets . Clcr 10 mL min 60 kg 100 mg day as 2 tablets 60 kg 75 mg day as 2 tablets EC capsules not recommended. Di-danosine is removed by hemodialysis but the quantity removed is low and supplemental doses are not recommended.97 Dosage Forms. Chew Dispersible Tab 25 50 100 150 200 mg EC Cap 125 200 250 400 mg Pwdr for Oral Soln 100 167 250 mg Pwdr for Oral Soln pediatric 2 4 g. Patient Instructions. See HIV Drugs Class Instructions. Didanosine must be taken on an empty stomach 1 hour before or 2 hours after a meal. It is essential that the 2-tablet dose be taken each time to avoid