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Báo cáo y học: "Community-wide analysis of microbial genome sequence signatures"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Wertheim cung cấp cho các bạn kiến thức về ngành y đề tài: Community-wide analysis of microbial genome sequence signatures. | Researc h Open Access Community-wide analysis of microbial genome sequence signatures Gregory J Dick Anders F Andersson Brett J Baker Sheri L Simmons Brian C Thomas A Pepper Yelton and Jillian F Banfield Addresses Department of Earth and Planetary Science University of California 307 McCone Hall Berkeley CA 94720 USA. Department of Environmental Science Policy and Management University of California Hilgard Hall Berkeley CA 94720 USA. Current address Department of Geological Sciences University of Michigan 1100 N. University Ave Ann Arbor MI 48109-1005 USA. Current address Evolutionary Biology Centre Department of Limnology Uppsala University Norbyv. 18 D SE-75236 Uppsala Sweden. Current address Department of Bacteriology Swedish Institute for Infectious Disease Control Nobels vag 18 SE-17182 Solna Sweden. Correspondence Gregory J Dick. Email gdick@umich.edu. Jillian F Banfield. Email jbanfield@berkeley.edu Published 21 August 2009 Genome Biology 2009 10 R85 doi l0.ll86 gb-2009-10-8-r85 The electronic version of this article is the complete one and can be found online at http genomebiology.com 2009 l0 8 R85 Received 29 April 2009 Revised 10 July 2009 Accepted 21 August 2009 2009 Dick et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Analyses of DNA sequences from cultivated microorganisms have revealed genome-wide taxa-specific nucleotide compositional characteristics referred to as genome signatures. These signatures have far-reaching implications for understanding genome evolution and potential application in classification of metagenomic sequence fragments. However little is known regarding the distribution of genome signatures in natural microbial communities or the extent to which environmental