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Báo cáo y học: "Ethanol extract of Scutellaria baicalensis Georgi prevents oxidative damage and neuroinflammation and memorial impairments in artificial senescense mice"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: Ethanol extract of Scutellaria baicalensis Georgi prevents oxidative damage and neuroinflammation and memorial impairments in artificial senescense mice | Jeong et al. Journal of Biomedical Science 2011 18 14 http www.jbiomedsci.eom content 18 1 14 tì.NSC The cost of publication in Journal of Biomedical Science Is borne by the National Science Council Taiwan JOURNAL OF BIOMEDICAL SCIENCE RESEARCH Open Access Ethanol extract of Scutellaria baicalensis Georgi prevents oxidative damage and neuroinflammation and memorial impairments in artificial senescense mice 11 11 1 1 2 2 3 Kukhuon Jeong Yong-Cheol Shin Sunju Park Jeong-Su Park Namil Kim Jae-Young Um Hoyeon Go Seungho Sun4 Sundong Lee4 Wansu Park5 Youkyung Choi5 Yunkyung Song5 Gyungjun Kim5 Chanyong Jeon5 Jonghyeong Park5 Keysang Lee6 Oksun Bang7 Seong-Gyu Ko1 8 Abstract Aging is a progressive process related to the accumulation of oxidative damage and neuroinflammation. We tried to find the anti-amnesic effect of the Scutellaria baicalens Georgia SBG ethanol extract and its major ingredients. The antioxidative effect of SBG on the mice model with memory impairment induced by chronic injection of D-galactose and sodium nitrate was studied. The Y-maze test was used to evaluate the learning and memory function of mice. The activities of superoxide dismutase catalase and the content of malondialdehyde in brain tissue were used for the antioxidation activities. Neuropathological alteration and expression of bcl-2 protein were investigated in the hippocampus by immunohistochemical staining. ROS neuroinflammation and apoptosis related molecules expression such as Cox-2 iNOS procaspase-3 cleaved caspase-3 8 and 9 bcl-2 and bax protein and the products of iNOS and Cox-2 NO PGE2 were studied using LPS-activated Raw 264.7 cells and microglia BV2 cells. The cognition of mice was significantly improved by the treatment of baicalein and 50 and 100 mg kg of SBG in Y-maze test. Both SBG groups showed strong antioxidation antiinflammation effects with significantly decreased iNOS and Cox-2 expression NO and PGE2 production increased bcl-2 and decreased bax and cleaved caspase-3 .