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Báo cáo y học: " The functional expression of extracellular calcium-sensing receptor in rat pulmonary artery smooth muscle cells"

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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: The functional expression of extracellular calcium-sensing receptor in rat pulmonary artery smooth muscle cells | Li et al. Journal of Biomedical Science 2011 18 16 http www.jbiomedsci.eom content 18 1 16 NSC The cost of publication in Journal of Biomedical Science Is borne by the National Science Council Taiwan JOURNAL OF BIOMEDICAL SCIENCE RESEARCH Open Access The functional expression of extracellular calcium-sensing receptor in rat pulmonary artery smooth muscle cells z I -1.2t 5t 2 IA1 w 2 2 2 2 2 Guang-wei Li Qiu-shi Wang Jing-hui Hao Wen-jing Xing Jin Guo Hong-zhu Li Shu-zhi Bai Hong-xia Li Wei-hua Zhang2 4 Bao-feng Yang3 4 Guang-dong Yang6 Ling-yun Wu2 6 Rui Wang2 6 Chang-qing Xu2 4 Abstract Background The extracellular calcium-sensing receptor CaSR belongs to family C of the G protein coupled receptors. Whether the CaSR is expressed in the pulmonary artery PA is unknown. Methods The expression and distribution of CaSR were detected by RT-PCR Western blotting and immunofluorescence. PA tension was detected by the pulmonary arterial ring technique and the intracellular calcium concentration Ca2 i was detected by a laser-scanning confocal microscope. Results The expressions of CaSR mRNA and protein were found in both rat pulmonary artery smooth muscle cells PASMCs and PAs. Increased levels of Ca2 o extracellular calcium concentration or Gd3 an agonist of CaSR induced an increase of Ca2 i and PAs constriction in a concentration-dependent manner. In addition the abovementioned effects of Ca2 and Gd3 were inhibited by U73122 specific inhibitor of PLC 2-APB specific antagonist of IP3 receptor and thapsigargin blocker of sarcoplasmic reticulum calcium ATPase . Conclusions CaSR is expressed in rat PASMCs and is involved in regulation of PA tension by increasing Ca2 i through G-PLC-IP3 pathway. Background Intracellular calcium a secondary messenger plays a key role in various physiological processes. Multiple studies have shown that extracellular calcium can act as a first messenger through the calcium-sensing receptor CaSR in various cells 1 . The CaSR belongs to the C family

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