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A–Z of Haematology - part 8

niêm mạc của MUD những vùng tiêu hóa, hô hấp và sinh dục phù hợp với các nhà tài trợ không liên quan (lưu ý: tình nguyện viên của nhà tài trợ không liên quan (VUD) là thuật ngữ thường dùng) đa kháng (MDR ) dựa trên sức đề kháng của tế bào di truyền các hành động của nhiều loại thuốc chống ung thư | MYC 165 mucosa-associated lymphoid tissue MALT lymphoid tissue associated with mucous membranes such as the pharynx larynx bronchi and small intestine mucous membrane mucosa the lining of the gastrointestinal respiratory and genitourinary tracts MUD matched unrelated donor note volunteer unrelated donor VUD is now the preferred terminology multidrug resistance MDR genetically-based resistance of cells to the actions of multiple anti-cancer drugs multiple myeloma a disseminated plasma cell neoplasm affecting predominantly the bone marrow most cases being characterized by synthesis of a monoclonal immunoglobulin a Bence Jones protein or both Fig. 54 in the WHO classification it is designated plasma cell myeloma multiplex PCR a PCR reaction using a number of pairs of primers so that a number of DNA segments can be amplified simultaneously multipotent myeloid stem cell a haemopoietic stem cell capable of giving rise to all myeloid lineages also know as the common myeloid progenitor MUM1 see IRF4 MUM2 3 see IRTA1 and IRTA2 murine relating to the mouse mutagen an agent capable of causing mutation mutagenic a description of an agent that can cause mutation mutation a structural alteration in the DNA of a cell either a germ cell or a somatic cell which can be transmitted to the fertilized gamete or to the progeny of the somatic cell MYB a gene avian Myeloblastosis viral oncogene homologue gene map locus 6q22 encodes a transcriptional activator protein c-MYB with sequence-specific DNA-binding activity that is expressed in haemopoietic precursor cells archetypal member of a small family of related genes including a-MYB at 8q22 expressed in germ cells and breast tissue and b-MYB at 20q13.1 ubiquitously expressed the c-MYB protein plays a key role in cell cycle control in haemopoi- Figure 54 Multiple myeloma. Laboratory investigations in multiple myeloma. Scanning densitometry of an electrophoretic strip top showing two bands in the early Y region arrow and late Y region .