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A–Z of Haematology - part 10

T một thụ thể tế bào T-αβ có khả năng nhận biết và ràng buộc một peptide kháng nguyên có nguồn gốc từ trong bối cảnh của một MHC tự thân (HLAencoded) phức tạp trên bề mặt của trình diện kháng nguyên tế bào; các phân tử thụ thể khác nhau của tế bào T-nhận ưu tiên peptide trong một HLA lớp I (với quy định của CD8 sau đó xảy ra) hoặc lớp bối cảnh | telomerase 215 of non-Hodgkin s lymphoma also expressed by osteoclasts TAX the transforming protein encoded by human T-cell leukaemia virus type I HTLV-I constitutively activates NFkB see also REL by binding to and chronically activating IkB kinase IkK an enzyme complex that phosphorylates and inactivates IkB thereby allowing NFkB to enter the nucleus TBI total body irradiation T cell a T lymphocyte T-cell receptor surface membrane receptors in T cells they are of two types ap and yS T cells with an ap T-cell receptor are capable of recognizing and binding an antigen-derived peptide in the context of an autologous MHC HLA-encoded complex on the surface of an antigen-presenting cell different T-cell receptor molecules recognize preferentially peptides in an HLA class I with up-regulation of CD8 then occurring or class II context with up-regulation of CD4 then occurring T chronic lymphocytic leukaemia a term which has been variously used to designate large granular lymphocyte leukaemia T prolymphocytic leukaemia and other entities to avoid ambiguity the use of this term is not recommended TCL1a T-Cell Leukaemia lymphoma 1a gene map locus 14q32.1 encodes a coactivator of the AKT kinase which is normally expressed in primitive B and T lymphocytes TCL1 is dysregulated in inv 14 q11q32 and t 14 14 q11 q32 associated with T-cell prolymphocytic leukaemia the dysregulation is consequent on the gene being brought into proximity to the TCRAD aS locus at 14q11 in addition to TCL1a three other genes normally expressed in primitive lymphoid cells and overexpressed in 14q32.1 rearrangements are present at this locus TCLlb T Cell Leukaemia lymphoma 1b encoding a homologue of TCLla TNG1 TCL1-Neighbounng Gene-1 and TNG2 TCL1-Neighbour-ing Gene-2 which encode proteins of unknown function TNG1 and TNG2 are sometimes collectively referred to as TCL6 TCL1b see TCLla TCL3 see HOX11 TCL6 see TCLla TCR T-cell receptor TCRAD aS the T-Cell Receptor Alpha Delta aS locus gene map locus 14q11 .